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KMID : 0894520170210040351
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Development & Reproduction
2017 Volume.21 No. 4 p.351 ~ p.359
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A Review of Mechanisms of Implantation
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Kim Su-Mi
Kim Jong-Soo
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Abstract
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Implantation is a highly organized process that involves an interaction between a receptive uterus and a com-petent blastocyst. In humans, natural fecundity suggests that the chance of conception per cycle is relatively low (~30%) and two-third of lost pregnancies occur because of implantation failure. Defective implantation leads to adverse pregnancy out-comes including infertility, spontaneous miscarriage, intrauterine fetal growth restriction and preeclampsia. With use of advanced scientific technologies, gene expression analysis and genetically-engineered animal models have revealed critical cellular networks and molecular pathways. But, because of ethical restrictions and the lack of a mechanistic experiment, comprehen-sive steps in human implantation have still not been completely understood. This review primarily focuses on the recent ad-vances in mechanisms of implantation. Because infertility is an emerging issue these days, gaining an understanding the mo-lecular and hormonal signaling pathway will improve the outcome of natural pregnancy and assisted reproductive technology.
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KEYWORD
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Implantation, Blastocyst, Endometrium, Uterine receptivity
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